Pediatric Blood & Marrow Transplantation Center
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Angela Panoskaltsis-Mortari, Ph.D.

Professor, Division of Pediatric Blood and Marrow Transplantation

Contact Dr. Panoskaltsis-Mortari

“I believe in the power of regenerative medicine. My goal is to help children breathe easier after transplant and I will continue to strive to relieve lung complications as long as I can.”

Dr. Panoskaltsis-Mortari is a Professor in the Department of Pediatrics, Division of Blood and Marrow Transplantation. Following her fellowship, she became a post-doctoral research associate in the Department of Pediatrics at the University of Minnesota. Dr. Panoskaltsis-Mortari has board certification from the American Board of Medical Laboratory Immunology and is the Director of the Cytokine Reference Laboratory. She is a member of the University of Minnesota Cancer Center, Center for Immunology, Lillehei Heart Institute, Institute for Engineering in Medicine and Stem Cell Institute.

Education

PhD: University of Western Ontario
Fellowship: University of Alabama, Department of Pathology
Fellowship: University of Minnesota, Pediatric BMT

Research Interests

Dr. Panoskaltsis-Mortari ‘s laboratory research focuses on the study of bone marrow transplant-related lung injury (idiopathic pneumonia syndrome & obliterative bronchiolitis) and the biology of graft-versus-host disease, both of which are major complications causing morbidity and mortality post-BMT. She is also exploring novel methods to bioengineer lungs for transplant. Currents interests include lung tissue bioengineering, small molecule & cellular therapies for post-transplant lung injury, and lung disease including idiopathic pulmonary fibrosis (IPF).

Publications and Awards

A selection of Dr. Panoskaltsis-Mortari ‘s recent publications.

Club Cell Secretory Protein improves Survival in a Murine Obliterative Bronchiolitis Model. Wendt C, Tram K, Price AP, England K, Stiehm A, Panoskaltsis-Mortari A. l.  Amer. J. Physiol: Lung Cell. Mol. Physiol., 305:642-650, 2013. doi: 10.1152/ajplung.00021.2013. Epub 2013 Aug 30.

Automated decellularization of intact, human-sized lungs for tissue engineering. Price AP, Godin LM, Domek A, Cotter T, Taylor DA, Panoskaltsis-Mortari A. Tissue Engineering, 2014. In revision.

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans.  Srinivasan M, Flynn R, Price A, Ranger A, Browning JL, Taylor PA, Ritz J, Antin JH, Murphy WJ, Luznik L, Shlomchik MJ, Panoskaltsis-Mortari A, Blazar BR.  Blood. 119(6):1570-80, 2012. doi: 10.1182/blood-2011-07-364414. Epub 2011 Nov 9.

Accelerated lung dysfunction and fibrosis in bone marrow transplant recipient mice deficient in MMP12. England KA, Price AP, Tram KV, Shapiro SD, Blazar BR, Panoskaltsis-Mortari A.  Amer. J. Physiol: Lung, Cell. Mol. Physiol. 301:L519-526, 2011. PMCID: doi: 10.1152/ajplung.00383.2009. Epub 2011 Jul 22.

An official ATS Research Statement: Non-infectious lung injury after hematopoietic stem cell transplantation: Idiopathic Pneumonia Syndrome.  Panoskaltsis-Mortari A chair, Griese M, Madtes DK, Belperio JA, Haddad IY, Folz RJ, Cooke KR.  Amer. J. Respiratory and Critical Care Medicine, 183:1262-1279, 2011. doi: 10.1164/rccm.2007-413ST.

Click here to see a complete list of Dr. Panoskaltsis-Mortari’s studies which have been published by academic and research journals. 


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