Paul Orchard, M.D.
Medical Director of the Inherited Metabolic & Storage Disease Bone Marrow Transplantation Program
Professor, Division of Pediatric Blood and Marrow Transplantation
“Ultimately, our program comes down to its people. I’m surrounded by a talented and energetic team who shares my belief that there are amazing possibilities to improve the transplant process and change the course of our young patients’ lives.”
“Ultimately, our program comes down to its people.
I’m surrounded by a talented and energetic team who shares my belief that there are amazing possibilities to improve the transplant process and change the course of our young patients’ lives.”
Dr. Orchard is interested in the use of blood and marrow transplantation (BMT) and potentially other cell therapies for inherited metabolic diseases, like Hurler syndrome and adrenoleukodystrophy. He has developed new therapies specifically for this group of patients with the goal of minimizing neurologic deterioration during the transplant process, including the use of anti-oxidants, reduced intensity transplant regimens and combinations of therapy such as transplant and enzyme replacement. This work also benefits other children undergoing transplant, particularly in regards to our commitment to minimize the side effects of transplantation.
Medical School: Brown University
Residency: University of Wisconsin - Madison (Pediatrics)
Fellowship: University of Minnesota (Hematology/Oncology and Bone Marrow Transplantation)
In addition to his clinical work with patients who have inherited metabolic diseases, Dr. Orchard is also engaged in more basic research studies in regard to determining strategies to enhance the delivery of enzymes to the brain and the peripheral nervous system for patients who lack specific enzymes. In addition, he is interested in testing other types of stem cells that may improve outcomes for patients with inherited diseases, including gene therapy approaches. He also leads research and clinical care for patients with osteopetrosis, an inherited disorder leading to increased density of bone, for which BMT is a treatment option. Dr. Orchard is considered an international expert in this disorder and its treatment.
A Selection of Dr. Orchard’s Recent Publications and Awards
Unexpected coronary artery findings in mucopolysaccharidosis. Report of four cases and literature review. Braunlin E, Orchard PJ, Whitley CB, Schroeder L, Reed RC, Manivel JC. Cardiovasc Pathol. 2014 Jan 10.
Effect of recombinant human growth hormone on changes in height, bone mineral density, and body composition over 1-2 years in children with Hurler or Hunter syndrome. Polgreen LE, Thomas W, Orchard PJ, Whitley CB, Miller BS. Mol Genet Metab. 2014 Feb.
Prospects for stem cell therapy in neuronal ceroid lipofuscinosis. Kruer MC, Pearce DA, Orchard PJ, Steiner RD. Regen Med. 2013 Sep.
Click here to see a complete list of Dr. Orchard’s studies which have been published by academic and research journals.
- Best Doctors in America® (2011, 2012, 2013)
- Mpls. St.Paul Magazine Top Doctors (2012)