Pediatric Blood & Marrow Transplantation Center
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Michael Kyba, Ph.D.

Professor, Division of Pediatric Blood and Marrow Transplantation

"Our research goal is to make new safe and effective stem cell therapies a reality."

Dr. Kyba is a Professor in the Department of Pediatrics, Division of Blood and Marrow Transplantation and the Lillehei Heart Institute. From 2003-2008, he was Assistant Professor of Developmental Biology at the University of Texas Southwestern Medical Center at Dallas, TX. He joined the faculty at the University of Minnesota in July 2008. He is active in the International Society for Stem Cell Research, American Society of Hematology and the American Heart Association.

Education

PhD: University of British Columbia Department of Zoology
Fellowship: Whitehead Institute, Massachusetts Institute of Technology

Research Interests

Dr. Kyba’s research laboratory focuses on regulation of tissue-specific stem cells (hematopoietic and skeletal muscle) with a view towards ex-vivo expansion and therapeutic transplantation, as well as the derivation of tissue-specific stem cells from embryonic or iPS cells. He is also developing methods of performing BMT without irradiation or chemical conditioning. He has performed seminal experiments establishing the proof of principle for hematopoietic stem cell repopulation using embryonic stem cells and maintains an active program in the development of gene-targeting / genetic correction / cell therapy models.

Publications and Awards

A Selection of Dr. Kyba’s Recent Awards and Publications

Publications

HoxA3 is an apical regulator of haemogenic endothelium. Iacovino M, Chong D, Szatmari I, Hartweck L, Rux D, Caprioli A, Cleaver O, Kyba M. Nat Cell Biol. 2011 Jan;13(1):72-8. doi: 10.1038/ncb2137. Epub 2010 Dec 19.

A new immuno- dystrophin-deficient model, the NSG-mdx4Cv mouse, provides evidence for functional improvement following allogeneic satellite cell transplantation. Arpke RW, Darabi R, Mader TL, Zhang Y, Toyama A, Lonetree C, Nash N, Lowe DA, Rita C.R. Perlingeiro, Kyba M. Stem Cells. 2013 31:1611-1620. doi: 10.1002/stem.1402.

A focal domain of extreme demethylation within D4Z4 in FSHD2. Hartweck LM, Anderson LJ, Lemmers RJ, Dandapat A, Toso EA, Dalton JC, Tawil R, Day JW, van der Maarel SM, Kyba M. Neurology. 2013 80:392-299. doi: 10.1212/WNL.0b013e31827f075c. Epub 2013 Jan 2.

Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner. Chan SS, Shi X, Toyama A, Arpke RW, Dandapat A, Iacovino M, Kang JJ, Le G, Hagen HR, Garry DJ, Kyba M. Cell Stem Cell. 2013 12:587-601. doi: 10.1016/j.stem.2013.03.004.

High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity. Bosnakovski D, Choi SH, Strasser JM, Toso EA, Walters MA, Kyba M. Skeletal Muscle. 2014 (1):4. doi: 10.1186/2044-5040-4-4.

Click here to see a complete list of Dr. Kyba’s studies which have been published by academic and research journals.

Awards

  • Medical Research Council of Canada Postdoctoral Fellowship (2000-2002)
  • Keystone Symposium Scholarship (X3-Stem Cells: Origins, Fates, Functions)( 2002)
  • Virginia Murchison Linthicum Scholar in Biomedical Research, UT SW Medical Center at Dallas (2003)
  • Basil O’Connor Starter Scholar Research Award, March of Dimes (2006)
  • Dr. Marvin and Hadassah Bacaner Research Award, Minnesota Medical Foundation (2010)

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Journey Clinic - Pediatric Blood and Marrow Transplantation Center

2450 Riverside Avenue
Minneapolis, MN 55454
612-365-1000
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