Pediatric Blood & Marrow Transplantation Center
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Jakub Tolar, M.D., Ph.D.

Tulloch Chair in Stem Cell Biology, Genetics and Genomics; Director, Stem Cell Institute
Professor, Department of Pediatric Blood & Marrow Transplantation

Dr. Tolar

“In order to cure the incurable, we need more than compassion – we need knowledge. That knowledge comes from research."

Dr. Tolar focuses on using hematopoietic stem cell transplant as a treatment for rare genetic disorders including Hurler syndrome, dyskeratosis congenital and has achieved international recognition for his work in caring for patients with recessive dystrophic epidermolysis bullosa.


Medical School: Charles University, Prague, Czech Republic
Doctor of Philosphy (PhD): University of Minnesota (Molecular, Cellular, Developmental Biology and Genetics)
Residency: University of Minnesota (Pediatrics)
Fellowship: University of Minnesota (Hematology/Oncology and Blood and Marrow Transplantation)

Clinical & Research Interests

Dr. Tolar is focused on integrating clinical observation, molecular biology, immunology, and laboratory research in studying and treating children with serious illness including cancer and other devastating genetic disorders.

Dr. Tolar is currently working on treatment protocols using hematopoietic stem cell transplant as a treatment for Hurler syndrome, Fanconi anemia, recessive dystrophic epidermolysis bullosa, dyskeratosis congenita, and severe aplastic anemia.

Publications and Awards

A Selection of Recent Awards and Publications

On Medawar's 'Actively acquired tolerance of foreign cells'. Tolar J, Tolarova S, McGrath JA. Exp Dermatol. 2014 Feb;23(2):97-8. doi: 10.1111/exd.12227.

Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa. Tolar J, McGrath JA, Xia L, Riddle MJ, Lees CJ, Eide C, Keene DR, Liu L, Osborn MJ, Lund TC, Blazar BR, Wagner JE. J Invest Dermatol. 2014 May;134(5):1246-54. doi: 10.1038/jid.2013.523. Epub 2013 Dec 6.

Allogeneic blood and bone marrow cells for the treatment of severe epidermolysis bullosa: repair of the extracellular matrix. Tolar J, Wagner JE. Lancet. 2013 Oct 5;382(9899):1214-23. doi: 10.1016/S0140-6736(13)61897-8. Review.

Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration. Aoyama K, Saha A, Tolar J, Riddle MJ, Veenstra RG, Taylor PA, Blomhoff R, Panoskaltsis-Mortari A, Klebanoff CA, Socié G, Munn DH, Murphy WJ, Serody JS, Fulton LM, Teshima T, Chandraratna RA, Dmitrovsky E, Guo Y, Noelle RJ, Blazar BR. Blood. 2013 Sep 19;122(12):2125-34. doi: 10.1182/blood-2012-11-470252. Epub 2013 Jun 27.

Bone Marrow Transplantation for Recessive Dystrophic Epidermolysis Bullosa. John E. Wagner, M.D., Akemi Ishida-Yamamoto, M.D., Ph.D., John A. McGrath, M.D., Maria Hordinsky, M.D., Douglas R. Keene, B.S., David T. Woodley, M.D., Mei Chen, Ph.D., Megan J. Riddle, B.A., Mark J. Osborn, Ph.D., Troy Lund, M.D., Ph.D., Michelle Dolan, M.D., Bruce R. Blazar, M.D., and Jakub Tolar, M.D., Ph.D. N Engl J Med 2010; 363:629-639August 12, 2010DOI: 10.1056/NEJMoa0910501

Click here to see a complete list of Dr. Tolar’s work which has been published by academic and research journals.


Best Doctors in America® (2011, 2012, 2013)
Mpls.St. Paul Top Doctors, 2012
Albert D. and Eva J. Corniea Chair, 2011-2016

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Journey Clinic - Pediatric Blood and Marrow Transplantation Center

2450 Riverside Avenue
Minneapolis, MN 55454
612-365-1000 TTY: 612-672-7300

For information about the Adult Blood and Marrow Transplantation program, click here:

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We have been providing innovative care to children in need of a blood and bone marrow transplant for over 50 years. Call us, we're here to help.

(888) 601-0787 or (612) 273-2800

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