Bruce Blazar, M.D.
Regents Professor, Division of Pediatric Blood and Marrow Transplantation
Director, Clinical and Translational Science Institute
Director, Center for Translational Medicine
“I want to develop new therapies that push the envelope of imagination to overcome complications of blood and marrow transplantation. By teamwork and being in a program that shares this vision, we can work together so that no child fails to realize a return to normal life.”
“I want to develop new therapies that push the envelope of imagination to overcome complications of blood and marrow transplantation.
By teamwork and being in a program that shares this vision, we can work together so that no child fails to realize a return to normal life.”
Dr. Blazar is an international leader in the development of novel, immune-based stem cell therapies to treat children with cancer and other rare diseases. With his team of research scientists, he vigorously investigates new ways to improve young patients’ experiences and outcomes through transplantation. He uses a combination of laboratory and clinical-based research to guide his work in developing new, innovative approaches to transplant care.
Medical School: Albany Medical College
Residency: University of Minnesota (Pediatrics)
Fellowship: University of Minnesota (Hematology/Oncology and Bone Marrow Transplantation)
Dr. Blazar is focused on developing new approaches to prevent graft-versus-host disease (GVHD) and to enhance immune system recovery after blood and marrow transplantation. His work also explores new strategies to prevent cancer relapse.
A selection of Dr. Blazar’s recent publications and awards
Human T regulatory cell therapeutic: take a billion or so and call me in the morning. Riley JL, June CH, Blazar BR. Immunity. 30:656-65, 2009.
Genetic trickery—Escape of leukemia from immune attack. Barrett JA, Blazar BR. N Engl J Med. 361:524-5, 2009.
Engineering lymphocyte subset: tools, trials and tribulations. June CH, Blazar BR, Riley JL: Nat Rev Immunol. 9:704-16, 2009.
Acute graft-versus-host disease: From the bench to the bedside. Socie G, Blazar BR. Blood 114:4327-36, 2009.
Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation? Ustun C, Miller JS, Munn DH, Weisdorf, DJ, Blazar BR. Blood 118:5084-95, 2011. PMID: 21881045 PMCD: PMC3217399.
Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. Srinivasan M, Flynn R, Price A, Ranger A, Browning JL, Taylor PA, Ritz J, Antin JH, Murphy WJ, Luznik L, Shlomchik MJ, Panoskaltsis-Mortari A*, Blazar BR* (co-last authors). Blood 119:1570-80, 2012 [cover photograph]. PMID: 22072556 PMCID: PMC3286218.
Advances in graft-versus-host disease biology and therapy. Blazar BR, Murphy WJ, Abedi M. Nat Rev Immunol 12:443-58, 2012.
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft vs host disease. Hanash AM, Dudakov JA, Hua G, O'Connor MH, Young LF, Singer NV, West ML, Jenq RR, Holland AM, Kappel LW, Ghosh A, Tsai JJ, Rao UK, Yim NL, Smith OM, Velardi E, Hawaryluk EB, Murphy GF, Lui C, Fouser LA, Kolesnick R, Blazar BR, van den Brink MR. Immunity 37:339-50, 2012
Control of acute myeloid leukemia relapse -- dance between KIRs and HLA. Miller JS, Blazar BR. N Engl J Med
Books: Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation. Socie G and Blazar BR (eds). Elsevier (pub), 2012.
Click here to see a complete list of Dr. Blazar’s studies which have been published by academic and research journals.
Edward Mallinckrodt, Jr. Foundation Scholar Award (1992-1995)
Member, NIH Immunobiology Study Section; Experimental Therapeutics-2 Study Section; Cancer Immunopathology and Immunotherapy Study Section (Chair)
Member, Leukemia and Lymphoma Society Translational Grant study section; Food and Drug Administration Biological Response Modifiers
MERIT Award, National Heart, Lung, and Blood Institute
Beutler Award and lectureship, American Society of Hematology
Till and McCullough Lecture Award, Canadian Blood and Marrow Transplant Group, 2013
Elected member of: Society for Pediatric Research; American Society of Clinical Investigation; Association of American Physicians; National Academy of Sciences Institute of Medicine